Decaffeinated light-roasted green coffee and green tea extract combination improved metabolic parameters and modulated inflammatory genes in metabolic syndrome rats

Background: Individually, green tea and coffee have been extensively studied for mitigation of metabolic syndrome (MS) in both rats humans; however, their combined effect requires further investigation. Thus, we compared the combining decaffeinated light roasted on MS rats. Methods: An animal model was constructed by feeding Sprague-Dawley with a high-fat-high-sucrose (HFHS) diet eight weeks low dose streptozotocin (STZ) injection at week 2. Rats fed HFHS diets injected STZ successfully developed phenotypes, indicated higher body weight, systolic blood pressure, plasma triglyceride level, fasting glucose lower HDL-C to those normal chow diet. Subsequently, were continuously divided into four groups: rats, 300 mg/bw.t extract (GT), 200 (GC), (CM) nine weeks. Results: Combining synergistic effects reducing level. Inflammatory markers liver tissue robustly decreased CM group rats. However, reduction pressure observed only GT groups. Moreover, all treatment resulted an increase level Conclusions: Our data highlighted that, models, augment several individual beneficial improved parameters modulated inflammatory genes.